Porcine NAMPT gene: search for polymorphism, mapping and association studies

0346215 - ÚŽFG 2011 RIV GB eng J - Článek v odborném periodiku
Čepica, Stanislav - Bartenschlager, H. - Óvilo, C. - Zrůstová, J. - Masopust, Martin - Fernández, A. - López, A. - Knoll, Aleš - Rohrer, G. A. - Snelling, W. M. - Geldermann, H.
Porcine NAMPT gene: search for polymorphism, mapping and association studies.
Animal Genetics. Roč. 41, č. 6 (2010), s. 646-651. ISSN 0268-9146. E-ISSN 1365-2052
Grant CEP: GA ČR GA523/07/0353
Výzkumný záměr: CEZ:AV0Z50450515
Klíčová slova: association study * carcass compositio * genetic mapping
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.203, rok: 2010

NAMPT encodes an enzyme catalysing the rate-limiting step in NAD biosynthesis. The extracellular form of the enzyme is known as adipokine visfatin. We detected SNP AM999341:g.669T>C (referred to as 669T>C) in intron 9 and SNP FN392209:g.358A>G (referred to as 358A>G) in the promoter of the gene. RH mapping linked the gene to microsatellite SW944. Linkage analysis placed the gene on the current USDA – USMARC linkage map at position 92 cM on SSC9. Association analyses were performed in a wild boar x Meishan F2 family (W x M), with 45 traits recorded (growth and fattening, fat deposition, muscling, meat quality, stress resistance and other traits), and in a commercial Landrace x Chinese-European (LCE) synthetic population with records for 15 traits (growth, fat deposition, muscling, intramuscular fat, meat colour and backfat fatty acid content).
Trvalý link: http://hdl.handle.net/11104/0187295