Noise exposure during early development impairs the processing of sound intensity in adult rats

0345712 - ÚEM 2011 RIV GB eng J - Článek v odborném periodiku
Bureš, Zbyněk - Grécová, Jolana - Popelář, Jiří - Syka, Josef
Noise exposure during early development impairs the processing of sound intensity in adult rats.
European Journal of Neuroscience. Roč. 32, č. 1 (2010), s. 155-164. ISSN 0953-816X. E-ISSN 1460-9568
Grant CEP: GA ČR GA309/07/1336; GA MŠMT(CZ) LC554
Grant ostatní: GA ČR(CZ) GD309/08/H079
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: auditory system * critical period * inferior colliculus
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.658, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0345712_01.pdf

The study demonstrates that exposure to intense noise at postnatal day 14 produced not only poorer frequency selectivity of neurons in the inferior colliculus (as reported previously by Grecova et al. (2009) Eur. J. Neurosci. 29, 1921–1930), but affected significantly the neuronal representation of sound intensity. Although the response thresholds were similar in the exposed and control rats, the neurons in the exposed animals had a longer first-spike latency, a narrower dynamic range, lower maximum response magnitudes and a steeper slope of the rate–intensity functions. The observed anomalies were confined to the mid- and high-frequency regions, whereas no significant changes were found in the low-frequency neurons.
Trvalý link: http://hdl.handle.net/11104/0186917