Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic AnhydraseInhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies

0343450 - ÚOCHB 2011 RIV US eng J - Článek v odborném periodiku
Gitto, R. - Agnello, S. - Ferro, S. - De Luca, L. - Vullo, D. - Brynda, Jiří - Mader, Pavel - Supuran, C. T. - Chimirri, A.
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic AnhydraseInhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies.
Journal of Medicinal Chemistry. Roč. 53, č. 6 (2010), s. 2401-2408. ISSN 0022-2623. E-ISSN 1520-4804
Grant CEP: GA ČR GA203/09/0820
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Klíčová slova: inhibitor design * crystal structure * X-ray analysis * dehalogenase
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 5.207, rok: 2010

This work explores inhibitory effects a small class of 1-(cyclo)alkylisoquinolines containing a sulfonamide function on the activity of carbonic anhydrase (CA, EC 4.2.1.1). Some derivatives showed potent hCA IX and hCA XIV inhibitory effects at nanomolar concentrations as well as low affinity for the ubiquitous hCA II. We also report the X-ray crystal structure of one of these derivatives in complex with dominant human isoform II.
Trvalý link: http://hdl.handle.net/11104/0185928