Astroglia in dementia and Alzheimer´s disease

0317550 - ÚEM 2010 RIV GB eng J - Článek v odborném periodiku
Rodríguez Arellano, Jose Julio - Olabarria, M. - Chvátal, Alexandr - Verkhratsky, Alexei
Astroglia in dementia and Alzheimer´s disease.
Cell Death and Differentiation. Roč. 16, č. 3 (2009), s. 378-385. ISSN 1350-9047. E-ISSN 1476-5403
Grant CEP: GA ČR GA305/06/1316; GA ČR GA305/06/1464; GA ČR GA309/08/1381; GA MŠMT(CZ) LC554; GA ČR GA305/08/1384
Grant ostatní: GA MŠk(CZ) 1M0538
Program: 1M
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: astrocyte * alia-Alzheimer´s disease * dementia
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 8.240, rok: 2009

Astrocytes, the most numerous cells in the brain, weave the canvas of the grey matter and act as the main element of the homoeostatic system of the brain. We show that in the transgenic model of Alzheimer's disease, reactive hypertrophic astrocytes surround the neuritic plaques, whereas throughout the brain parenchyma astroglial cells undergo atrophy. Astroglial atrophy may account for early changes in synaptic plasticity and cognitive impairments, which develop before gross neurodegenerative alterations.
Trvalý link: http://hdl.handle.net/11104/0167164