Defining the glycophenotype of squamous epithelia using plant and mammalian lectins. Differentiation-dependent expression of alpha2,6- and alpha2,3-linked N-acetylneuraminic acid in squamous epithelia and carcinomas, and its differential effect on binding of the endogenous lectins galectins-1 and -3

0213503 - UZFG-Y 20023119 RIV DK eng J - Článek v odborném periodiku
Motlík, Jan - Holíková, Z. - Hrdličková-Cela, E. - Plzák, J. - Smetana Jr., K. - Betka, J. - Dvořánková, B. - Esner, M. - Wasano, K. - André, S. - Kaltner, H. - Hercogová, J. - Kodet, R. - Gabius, H. J.
Defining the glycophenotype of squamous epithelia using plant and mammalian lectins. Differentiation-dependent expression of alpha2,6- and alpha2,3-linked N-acetylneuraminic acid in squamous epithelia and carcinomas, and its differential effect on binding of the endogenous lectins galectins-1 and -3.
Acta Pathologica Microbiologica et Immunologica Scandinavica. Roč. 110, - (2002), s. 845-856. ISSN 0903-4641. E-ISSN 1600-0463
Grant CEP: GA ČR GA304/02/0463; GA MŠMT LN00A065; GA AV ČR KSK5052113
Klíčová slova: epidermis * galectin * glycohistochemistry
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 0.968, rok: 2002

A thorough characterization of the properties of squamous epithelial cell is necessary in order to improve our understanding of the functional aspects of normal development and malignant aberrations. With our growing awareness of the coding function of glycan chains of cellular glycoconjugates and their interaction with receptors (lectins) in situ, defining the glycophenotype of these cells has become an important issue. Whwreas the commonly applied plant lectins are tools used to map the presence and location of biochemically defined saccharide epitopes, the introduction of endogenous (mammalian) lectins to this analysis enables us to take the step from monitoring the presence of glycan to understanding the functional implications by revealing ligand properties of the detected epitope for issue lectin.
Trvalý link: http://hdl.handle.net/11104/0109039