0211580 - UT-L 20000216 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Pásek, Michal - Šimurda, J.
Effect of block of fast sidium current and transient potassium current on configuration of action voltage in cardiac cell (computer modelling).
Engineering mechanics 2000. Vol. 3. Praha: UTAM AV ČR, 2000 - (Náprstek, J.; Minster, J.), s. 87-90. ISBN 80-86246-06-X.
[International conference Engineering mechanics 2000. Svratka (CZ), 15.05.2000-18.05.2000]
Grant ostatní: ÚT AV ČR(XC) PP 20/7U
Výzkumný záměr: CEZ:AV0Z2076919
Klíčová slova: quantitative modelling * membrane channels * carrdiac cell
Kód oboru RIV: BO - Biofyzika

The aim of this study is to explore the effect of propafenone - induced block of fast sodium current (INa) and 4-aminopyridine - induced block of transient potassium current (IKto) on action voltage configuration in mammalian cardiac cells. The presented results are based on the computer simulation of above currents and action voltages under conditions of presence and absence of the blockers. This approach contributes to better understanding of the mechanisms underling suppression of cardiac arrhythmias.
Trvalý link: http://hdl.handle.net/11104/0107129