Počet záznamů: 1  

Structural Studies of anti-CA IX Monoclonal Antibody M75 Fab Fragment in Complex with its Epitope Peptide

  1. 1.
    0191698 - UMG-J 20033217 RIV SIGLE CZ eng K - Konferenční příspěvek (tuzemská konf.)
    Mader, Pavel - Štouračová, Renata - Brynda, Jiří - Závada, Jan
    Structural Studies of anti-CA IX Monoclonal Antibody M75 Fab Fragment in Complex with its Epitope Peptide.
    2004. In: Materials Structure in Chemistry, Biology, Physics and Technology., s. 62. ISSN 1211-5894.
    [Meeting of the Czech and Slovak structural biologists /3./. Nové hrady (CZ), 11.03.2004-13.03.2004]
    Grant CEP: GA ČR GA203/02/0405
    Výzkumný záměr: CEZ:AV0Z5052915
    Klíčová slova: CAIX * antibody * structure
    Kód oboru RIV: CE - Biochemie

    CA IX is a cell surface protein that exerts capacity of binding cell surface receptors, and is associated with several types of human carcinomas. Monoclonal antibody M75 recognizes specifically an epitope identified as six repeats of amino acid sequence PGEEDLP, localized in the proteoglycan like domain of CA IX. Structural study of the M75 Fab fragment in complex with its epitope peptide PGEEDLPGEEDL is presented.
    Trvalý link: http://hdl.handle.net/11104/0087435