0172265 - UEB-Q 20023050 RIV GB eng J - Článek v odborném periodiku
Maďarová, J. - Lukešová, M. - Hlobilková, A. - Strnad, Miroslav - Vojtěšek, B. - Lenobel, R. - Hajdúch, M. - Murray, P. G. - Perera, S. - Kolář, Z.
Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.
Journal of Clinical Pathology - Molecular Pathology. Roč. 55, č. 4 (2002), s. 227-234. ISSN 1366-8714
Grant CEP: GA ČR GA301/02/0475
Výzkumný záměr: CEZ:AV0Z5038910
Klíčová slova: synthetic CDK inhibitors * cell cycle * apoptosis
Kód oboru RIV: EB - Genetika a molekulární biologie

Because of the high prevalence of prostatic cancer and the limitations of its treatment, enormous effort has been put into the development of new therapeutic modalities. One potential tool is the use of cyclin dependent kinase (CDK) inhibitors, which are based on the trisubstituted derivatives of purine. The aim of this study was to analyse alterations of the regulatory pathways in both androgen sensitive and androgen insensitive prostatic cancer cell lines (LNCaP and DU-145, respectively) after blockage of the cell cycle by the synthetic CDK inhibitors, olomoucine and bohemine.
Trvalý link: http://hdl.handle.net/11104/0069304