0172221 - UEB-Q 20023003 RIV AT eng J - Článek v odborném periodiku
Franěk, František - Katinger, H.
Specific Effects of Synthetic Oligopeptides on Cultured Animal Cells.
Biotechnology Progress. Roč. 18, - (2002), s. 155-158. ISSN 8756-7938. E-ISSN 1520-6033
Grant CEP: GA MŠMT OC 844.10
Výzkumný záměr: CEZ:AV0Z5038910
Klíčová slova: Oligopeptides * Animal Cells
Kód oboru RIV: CE - Biochemie
Impakt faktor: 1.734, rok: 2002

Synthetic oligopeptides, tri- to pentaglycine and tri- and tetraalanine, were found to enhance viable cell density and culture viability when applied at concentrations higher than milllimolar to the cultures of a model hybridoma line. Oligoalanines, in addition, enhanced monoclonal antibody yields. Oligoglycines promoted solely the cell growth, unless the batch culture was fed with a medium concentrate. Examination of the effects of various tripeptides composed of glycine, alanine, serine, threonine, lysine, and histidine showed that some of the peptides promoted the growth of the culture, while other peptides suppressed the growth and enhanced the monoclonal antibody yield.
Trvalý link: http://hdl.handle.net/11104/0069260