0172211 - UEB-Q 20013090 RIV SIGLE SE eng M - Část monografie knihy
Kolářová, H. - Kubínek, R. - Navrátil, L. - Strnad, Miroslav - Réblová, K. - Škopek, J.
Laser-induced photodynamic effect.
Laser Florence 2000: A window on the laser Medicine World (Proceedings of SPIE, vol. 4606). Cincinaty: The International Society for Optical Engineering, 2001, s. 144-147
Grant CEP: GA ČR GA203/00/0152; GA ČR GA522/01/0275
Výzkumný záměr: CEZ:AV0Z5038910
Klíčová slova: photodynamic effect
Kód oboru RIV: BO - Biofyzika

Photodynamic therapy is a treatment that is used for destruction of certain tumors. The treatment is performed with photosensitizers that generate reactive oxygen species in the presence of light and oxygen. The absorption and fluorescence spectra of the ClAlPcS2 and ZnPcS2 photosensitizers were measured. From this analysis a semiconductor laser emitting a beam of 50 mW cw power at the wavelength of 675 nm for our experiments was chosen, because this wavelength corresponded with the absorption maximum (675 nm) in long-wave region of the visible part of electromagnetic spectra. B16 (cells line of mouse melanoma) was chosen as a standard testing system for definition of the in vitro phototoxicity after photodynamic reaction. The optimal phototoxic effect on B16 cells was observed at 2 (mu) g/ml ClAlPcS2 in combination with laser irradiation of 10 J/cm2.
Trvalý link: http://hdl.handle.net/11104/0069253