0142418 - FGU-C 20030010 RIV US eng J - Článek v odborném periodiku
Ueno, T. - Tremblay, J. - Kuneš, Jaroslav - Zicha, Josef - Dobešová, Zdenka - Pausova, Z. - Deng, A. Y. - Sun, Y. L. - Jacob, H. J. - Hamet, P.
Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems.
Journal of Molecular Medicine-Jmm. Roč. 81, č. 1 (2003), s. 51-60. ISSN 0946-2716. E-ISSN 1432-1440
Grant CEP: GA AV ČR IAA7011711
Grant ostatní: CIHR(CA) MOP-11463; CIHR(CA) MT-12574; CIHR(CA) MOP-36378; AHA(US) AD-12-FMCQ 0140149N
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: genetic analysis * blood pressure * vasoactive system balance
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 4.101, rok: 2003

Pharmacogenetic analysis was carried out in F2 hybrid population derived from Prague hypertensive hypertriglyceridemic and normotensive normolipidemic Lewis rats. Several quantitative trait loci for particular blood pressure components (dependent on renin-angiotensin system, sympathetic nervous system or nitric oxide) were disclosed. This pharmacogenetic approach should enable to determine the main causative blood pressure regulating systems in hypertension.
Trvalý link: http://hdl.handle.net/11104/0040122