0142412 - FGU-C 20030004 RIV NL eng J - Článek v odborném periodiku
Ježek, Petr - Ježek, Jan
Sequence anatomy of mitochondrial anion carriers.
FEBS Letters. Roč. 534, 1-3 (2003), s. 15-25. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA AV ČR IAA5011106; GA ČR GA301/02/1215; GA MŠMT ME 389
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: mitochondrial anion carriers * carrier genomics * bioinformatics
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.609, rok: 2003

284 genes of eight eukaryotic genomes for mitochondrial anion carriers were sorted into 43 (+18 single protein) subfamilies. Subfamilies differ by the number, nature, and locations of charges and polar residues in the transmembrane alfa-helices. Consequently, these residues and the rarely unique residues of the matrix and cytosolic segments most likely determine the different molecular phenotypes (functions). Common ancestral hydrophilic segments were found in matrix and cytosolic segments, with interchangeable polar residues. Thus the hydrophobic microstructures of hydrophilic carrier parts are supposed to pre-determine structure/conformation, whereas polar and charged microstructures should pre-determine function, namely in the transmembrane spanning alfa-helices.
Trvalý link: http://hdl.handle.net/11104/0040116