Počet záznamů: 1  

Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

  1. 1.
    0142235 - FGU-C 20010295 RIV US eng J - Článek v odborném periodiku
    Koistinaho, M. - Ort, Michael - Cimadevilla, Jose Maria - Vondrous, R. - Cordell, B. - Koistinaho, J. - Bureš, Jan - Higgins, L.
    Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques.
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 98, č. 4 (2001), s. 14675-14680. ISSN 0027-8424
    Grant CEP: GA ČR GA309/00/1656
    Výzkumný záměr: CEZ:AV0Z5011922
    Klíčová slova: spatial memory * transgenic mice * alzheimer
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 10.890, rok: 2001

    Transgenic mice expressing human beta-amyloid precursor protein were impaired in water maze navigation although they did not form plaques. The impairment increased with age from 3 to 24 months.
    Trvalý link: http://hdl.handle.net/11104/0039942