Assembling a clock for all seasons: are there M and E oscillators in the genes?

0142126 - FGU-C 20010178 RIV US eng J - Článek v odborném periodiku
Daan, S. - Albrecht, U. - van der Horst, G. T. - Illnerová, Helena - Roenneberg, T. - Wehr, T. A. - Schwartz, W. J.
Assembling a clock for all seasons: are there M and E oscillators in the genes?
Journal of Biological Rhythms. Roč. 16, č. 2 (2001), s. 105-116. ISSN 0748-7304. E-ISSN 1552-4531
Grant CEP: GA ČR GA309/00/1655
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: evening/morning oscillators * circadian clock genes * pacemaker
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.695, rok: 2001

The hypothesis is advanced that the circadian pacemaker in the mammalian suprachiasmatic nucleus (SCN) is composed at molecular level of a double complex of circadian genes (per1/cry1 and per2/cry2). Each one of these sets would be sufficient for the maintenance of endogenouss rhythmicity and thus constitute an oscillator. The per1/cry1 oscillator is accelerated by light (morning oscillator). and per2/cry2 oscillator is decelerated by light (evening oscillator). These oscillators would give rise to the SCN's neuronal activity in an morning and evening component.
Trvalý link: http://hdl.handle.net/11104/0039835