Počet záznamů: 1  

Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells

  1. 1.
    0127067 - BFU-R 20033155 RIV US eng J - Článek v odborném periodiku
    Taslerová, R. - Kozubek, Stanislav - Lukášová, Emilie - Jirsová, Pavla - Bártová, Eva - Kozubek, Michal
    Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells.
    Human Genetics. Roč. 112, č. 2 (2003), s. 143-155. ISSN 0340-6717
    Grant CEP: GA MZd NC5955; GA AV ČR IBS5004010; GA ČR GA301/01/0186
    Výzkumný záměr: CEZ:AV0Z5004920
    Klíčová slova: high-resolution cytometry * human leukemic cells * Ewing sarcoma cells
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.022, rok: 2003

    Standard and repeated fluorescence in situ hybridization and high-resolution cytometry were used to study topographical parameters of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells. HSA 11 and its elements (BCL1, FLI1, centromere) were found, on average, more peripherally in comparison with HSA 22 and investigated elements (BCR, EWSR1, centromere). After the elimination of fluctuations of chromosome territories in nuclear volume, it was found that genetic elements in most cases adhered to their territories. The investigated genetic elements of HSA 11 were found close to each other relative to the large molecular lengths among them. This finding indicates a higher degree of chromatin condensation of at least a part of HSA 11 compared with HSA 22.
    Trvalý link: http://hdl.handle.net/11104/0025290