Počet záznamů: 1

Relationship between haematological profile and progression or spontaneous regression of melanoma in the Melanoma-bearing Libechov Minipigs

SYSNO ASEP	0512114
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Relationship between haematological profile and progression or spontaneous regression of melanoma in the Melanoma-bearing Libechov Minipigs
Tvůrce(i)	Čížková, Jana (UZFG-Y) Erbanová, Michaela (UZFG-Y) Sochor, J. (CZ) Jindrová, A. (CZ) Strnadová, K. (CZ) Horák, Vratislav (UZFG-Y)_{RID, ORCID}
Zdroj.dok.	Veterinary Journal. - : Elsevier - ISSN 1090-0233 Roč. 249, JUL (2019), s. 1-9
Poč.str.	9 s.
Forma vydání	Tištěná - P
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	cancer progression and spontaneous regression ; haematological parameters ; pig melanoma
Vědní obor RIV	FD - Onkologie a hematologie
Obor OECD	Oncology
CEP	LO1609 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Způsob publikování	Omezený přístup
Institucionální podpora	UZFG-Y - RVO:67985904
UT WOS	000474309600001
EID SCOPUS	85065543181
DOI	10.1016/j.tvjl.2019.04.016
Anotace	Haematological parameters, plasma iron concentration, and bodyweight were monitored in Melanomabearing Libechov Minipigs (MeLiM) from 5 to 18 weeks old. Animals with melanoma progression (P group) and spontaneous regression (SR group) were compared. The P group showed the lowest median values of red blood cell counts (RBC), haematocrit (HCT), haemoglobin concentration (HGB), and bodyweight, whereas the control white (tumour-free) pigs (C group) revealed the highest mean values of these parameters. The mean values of pigs with SR fell between the P and C groups. In addition, a stable concentration of plasma iron was found in the C group, while iron deficiency that increases with age was observed in the MeLiM groups. These results indicate that MeLiM are affected by cancer-related microcytic hypochromic anaemia. The lowest values of HGB, RBC, and HCT, together with the highest number of platelets (PLT) in the P group correspond to melanoma progression. Higher values of these parameters and lower PLT in the MeLiM pigs with SR reflected health improvement due to the destruction of melanoma cells during spontaneous regression. Monitoring of these haematological parameters can help distinguish MeLiM piglets with progression and spontaneous regression of melanoma in the early stages of postnatal development. The findings of this study correspond to findings in human patients in which cancer-related anaemia, thrombocytosis, and iron deficiency are often diagnosed.
Pracoviště	Ústav živočišné fyziologie a genetiky
Kontakt	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru	2020
Elektronická adresa	https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=55752948996

Počet záznamů: 1