Počet záznamů: 1
The role of gut microbiota in intestinal and liver diseases
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SYSNO ASEP 0507943 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of gut microbiota in intestinal and liver diseases Tvůrce(i) Hrnčíř, Tomáš (MBU-M) RID, ORCID
Hrnčířová, Lucia (MBU-M)
Kverka, Miloslav (MBU-M) RID, ORCID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDZdroj.dok. Laboratory Animals. - : Sage - ISSN 0023-6772
Roč. 53, č. 3 (2019), s. 271-280Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova inflammatory bowel disease ; cancer ; coeliac disease Vědní obor RIV EC - Imunologie Obor OECD Immunology CEP GA15-09518S GA ČR - Grantová agentura ČR GA15-07268S GA ČR - Grantová agentura ČR GA16-06326S GA ČR - Grantová agentura ČR GA17-07332S GA ČR - Grantová agentura ČR GA17-09869S GA ČR - Grantová agentura ČR NV15-28064A GA MZd - Ministerstvo zdravotnictví NV15-30782A GA MZd - Ministerstvo zdravotnictví NV17-31248A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000469385000006 EID SCOPUS 85067175217 DOI 10.1177/0023677218818605 Anotace The world-wide incidence of many immune-mediated and metabolic diseases, including those of the intestines and liver, is steadily increasing. Gut microbiota plays a central role in the pathogenesis of these diseases as it mediates environmental changes to the intestinal immune system. Various environmental factors including diet, food additives and medication also trigger the compositional and functional alterations of microbiota, that is, dysbiosis, and this dysbiosis is closely associated with many chronic inflammatory diseases. However, the causal relationship remains unclear for the majority of these diseases. In this review, we discuss essential epidemiological data, known pathogenetic factors including those of genetic and environmental nature, while mainly focusing on the role of gut microbiota in the development of selected intestinal and liver diseases. Using specific examples, we also briefly describe some of the most widely-used animal models including gnotobiotic models and their contribution to the research of pathogenetic mechanisms of the host-microbiota relationship. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://journals.sagepub.com/doi/10.1177/0023677218818605
Počet záznamů: 1