Počet záznamů: 1
Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties
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SYSNO ASEP 0507891 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties Tvůrce(i) Chambers, Christopher S. (MBU-M) RID, ORCID
Biedermann, David (MBU-M) RID, ORCID
Valentová, Kateřina (MBU-M) RID, ORCID
Petrásková, Lucie (MBU-M) ORCID
Viktorová, J. (CZ)
Kuzma, Marek (MBU-M) ORCID, RID
Křen, Vladimír (MBU-M) RID, ORCIDČíslo článku 236 Zdroj.dok. Antioxidants. - : MDPI
Roč. 8, č. 7 (2019)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova carotenoids ; retinol ; flavonolignans Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry CEP LTC17009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000478608600020 DOI 10.3390/antiox8070236 Anotace Antioxidants protect the structural and functional components in organisms against oxidative stress. Most antioxidants are of plant origin as the plants are permanently exposed to oxidative stress (UV radiation, photosynthetic reactions). Both carotenoids and flavonoids are prominent antioxidant and anti-radical agents often occurring together in the plant tissues and acting in lipophilic and hydrophilic milieu, respectively. They are complementary in their anti-radical activity. This study describes the synthesis of a series of hybrid ester conjugates of retinoic acid with various flavonolignans, such as silybin, 2,3-dehydrosilybin and isosilybin. Antioxidant/anti-radical activities and bio-physical properties of novel covalent carotenoid-flavonoid hybrids, as well as various mixtures of the respective parent components, were investigated. Retinoyl conjugates with silybin-which is the most important flavonolignan in silymarin complex-(and its pure diastereomers) displayed better 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than both the parent compounds and their equimolar mixtures. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://www.mdpi.com/2076-3921/8/7/236
Počet záznamů: 1