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Coxiella burnetii immunogenic proteins as a basis for new Q fever diagnostic and vaccine development
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SYSNO ASEP 0506532 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Coxiella burnetii immunogenic proteins as a basis for new Q fever diagnostic and vaccine development Tvůrce(i) Gerlach, C. (DE)
Škultéty, L'udovít (MBU-M) ORCID, RID
Henning, K. (DE)
Neubauer, H. (DE)
Mertens, K. (DE)Zdroj.dok. Acta virologica - ISSN 0001-723X
Roč. 6, č. 3 (2017), s. 377-390Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. SK - Slovensko Klíč. slova Coxiella burnetii ; proteomic analysis ; immunoreactive proteins Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000411298700021 EID SCOPUS 85028608955 DOI 10.4149/av_2017_320 Anotace Coxiella burnetii is the etiological agent of the zoonosis Q fever, which can cause an acute or a chronic, life-threatening disease in humans. It presents a highly stable cell form, which persists in the environment and is transmitted via contaminated aerosols. Ruminants are considered as the main reservoir for human infections but are usually asymptomatic. Subclinical infection in these animals and the occurrence of serologically negative shedders hamper the identification of infected animals with the currently used diagnostic techniques. This suboptimal sensitivity limits reliable identification of infected animals as well as the well-timed implementation of countermeasures. This review summarizes compounds, focusing on C. burnetii seroreactive proteins, which were discovered in recent immunoproteomic studies. We analyzed these proteins regarding their localization, function, frequency of citation, differences seen in various host species as well as sensitivity and specificity. Finally, proteins useful for the development of new diagnostic test systems as well as subunit vaccines were discussed. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa 85028608955
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