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The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies
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SYSNO ASEP 0501003 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies Tvůrce(i) Artero-Castro, A. (ES)
Popelka, Štěpán (UMCH-V) RID
Jendelová, Pavla (UEM-P) RID, ORCID
Motlík, Jan (UZFG-Y) RID, ORCID
Ardan, Taras (UZFG-Y) RID, ORCID
Rodriguez Jimenez, F. J. (ES)
Erceg, Slaven (UEM-P) RID, ORCIDZdroj.dok. Expert Opinion on Drug Discovery. - : Taylor & Francis - ISSN 1746-0441
Roč. 14, č. 2 (2019), s. 169-177Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova hiPSCs ; retinal pigment epithelial cells ; retinal dystrophies Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Vědní obor RIV – spolupráce Ústav experimentální medicíny - Neurologie, neurochirurgie, neurovědy
Ústav živočišné fyziologie a genetiky - ORL, oftalmologie, stomatologieCEP GA18-04393S GA ČR - Grantová agentura ČR LO1609 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 ; UEM-P - RVO:68378041 ; UZFG-Y - RVO:67985904 UT WOS 000457031800008 EID SCOPUS 85060640152 DOI 10.1080/17460441.2019.1559148 Anotace Combinatory strategies using pharmacology and stem cell therapy have emerged due to their potential in the treatment of retinal pigment epithelium (RPE) cell related diseases, and a variety of different stem cell sources have been evaluated both in animal models and in humans. RPE cells derived from human embryonic stem cells (hESCs) and human induced pluripotent cells (hiPSCs) are already in clinical trials, holding great promise for the treatment of age-related macular disease (AMD) and hereditary RPE-related retinal dystrophies. Highly efficient protocol for RPE generations have been developed, but they are still time-consuming and laborious. The authors review RPE related diseases, as well as the known functions of RPE cells in retinal homeostasis. The authors also discuss small molecules that target RPE in vivo as well as in vitro to aid RPE differentiation from pluripotent stem cells clinically. The authors base this review on literature searches performed through PubMed. Using high-throughput systems, technology will provide the possibility of identifying and optimizing molecules/drugs that could lead to faster and simpler protocols for RPE differentiation. This could be crucial in moving forward to create safer and more efficient RPE-based personalized therapies. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2020 Elektronická adresa https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1559148
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