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The Oomycete Pythium oligandrum Can Suppress and Kill the Causative Agents of Dermatophytoses

SYSNO ASEP	0494047
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	The Oomycete Pythium oligandrum Can Suppress and Kill the Causative Agents of Dermatophytoses
Tvůrce(i)	Gabrielová, Alena (MBU-M) Mencl, K. (CZ) Suchánek, M. (CZ) Klimeš, R. (CZ) Hubka, Vít (MBU-M)_ORCID Kolařík, Miroslav (MBU-M)_{RID, ORCID}
Zdroj.dok.	Mycopathologia - ISSN 0301-486X Roč. 183, č. 5 (2018), s. 751-764
Poč.str.	14 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	Pythium oligandrum ; Dermatophytes ; Mycoparasitism
Vědní obor RIV	EE - Mikrobiologie, virologie
Obor OECD	Microbiology
CEP	NV17-31269A GA MZd - Ministerstvo zdravotnictví
Institucionální podpora	MBU-M - RVO:61388971
UT WOS	000444461100002
EID SCOPUS	85049555329
DOI	10.1007/s11046-018-0277-2
Anotace	Pythium oligandrum (Oomycota) is known for its strong mycoparasitism against more than 50 fungal and oomycete species. However, the ability of this oomycete to suppress and kill the causal agents of dermatophytoses is yet to be studied. We provide a complex study of the interactions between P. oligandrum and dermatophytes representing all species dominating in the developed countries. We assessed its biocidal potential by performing growth tests, on both solid and liquid cultivation media and by conducting a pilot clinical study. In addition, we studied the molecular background of mycoparasitism using expression profiles of genes responsible for the attack on the side of P. oligandrum and the stress response on the side of Microsporum canis. We showed that dermatophytes are efficiently suppressed or killed by P. oligandrum in the artificial conditions of cultivations media between 48 and 72h after first contact. Significant intra- and interspecies variability was noted. Of the 69 patients included in the acute regimen study, symptoms were completely eliminated in 79% of the patients suffering from foot odour, hyperhidrosis disappeared in 67% of cases, clinical signs of dermatomycoses could no longer be observed in 83% of patients, and 15% of persons were relieved of symptoms of onychomycosis. Our investigations provide clear evidence that the oomycete is able to recognize and kill dermatophytes using recognition mechanisms that resemble those described in oomycetes attacking fungi infecting plants, albeit with some notable differences.
Pracoviště	Mikrobiologický ústav
Kontakt	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Rok sběru	2019

Počet záznamů: 1