Počet záznamů: 1

Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View

SYSNO ASEP	0478167
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View
Tvůrce(i)	Cebecauer, Marek (UFCH-W)_{RID, ORCID, SAI} Hof, Martin (UFCH-W)_{RID, ORCID} Amaro, Mariana (UFCH-W)_{RID, ORCID}
Zdroj.dok.	Biophysical Journal. - : Cell Press - ISSN 0006-3495 Roč. 113, č. 6 (2017), s. 1194-1199
Poč.str.	6 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	SURFACE-PLASMON RESONANCE ; ALZHEIMERS-DISEASE ; GM1 GANGLIOSIDE
Vědní obor RIV	BO - Biofyzika
Obor OECD	Biophysics
CEP	GA17-03160S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	UFCH-W - RVO:61388955
UT WOS	000411064500007
EID SCOPUS	85017394553
DOI	10.1016/j.bpj.2017.03.009
Anotace	In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.
Pracoviště	Ústav fyzikální chemie J.Heyrovského
Kontakt	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Rok sběru	2018

Počet záznamů: 1