Počet záznamů: 1

High resolution X-ray micro-CT imaging of fibrin scaffold using large area single photon counting detector

SYSNO ASEP	0497929
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	High resolution X-ray micro-CT imaging of fibrin scaffold using large area single photon counting detector
Tvůrce(i)	Vavřík, Daniel (UTAM-F)_{RID, SAI, ORCID} Kytýř, Daniel (UTAM-F)_{SAI, RID, ORCID} Mühleder, S. (AT) Vopálenský, Michal (UTAM-F)_{RID, ORCID, SAI} Beneš, Pavel (UTAM-F)_{RID, SAI} Pichotka, M. (CZ) Kumpová, Ivana (UTAM-F)_{RID, SAI, ORCID} Koudelka_ml., Petr (UTAM-F)_{RID, SAI, ORCID}
Celkový počet autorů	8
Číslo článku	C12006
Zdroj.dok.	Journal of Instrumentation. - : Institute of Physics Publishing - ISSN 1748-0221 Roč. 13, č. 12 (2018)
Poč.str.	12 s.
Forma vydání	Tištěná - P
Akce	International Workshop on Radiation Imaging Detectors /20./
Datum konání	24.06.2018 - 28.06.2018
Místo konání	Sundsvall
Země	SE - Švédsko
Typ akce	WRD
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	computerized tomography (CT) ; computed radiography (CR) ; pixelated detectors ; VLSI electronics ; inspection with x-rays
Vědní obor RIV	JJ - Ostatní materiály
Obor OECD	Applied mechanics
CEP	EF16_019/0000766 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
UT WOS	000452801600001
EID SCOPUS	85059917084
DOI	10.1088/1748-0221/13/12/C12006
Anotace	This paper deals with the high resolution X-ray micro-computed tomographical (micro-CT) visualization of a fibrin scaffold intended to be used during medical repairs of various types of human tissue. Due to the cellular nature of scaffolds, it is important to inspect their Microstructure in high detail on a volumetric basis. In this work, we demonstrate the micro-CT measurement of a fibrin-based bone scaffold performed using a proprietarily developed tomographical scanner equipped with a large-area imaging device (LAD) composed of 10 x 10 Timepix silicon pixel detectors without any gaps between the individual tiles. The fibrin scaffolds are based on organic materials, which may be reinforced by various additives to improve their mechanical characteristics, and their dimensions are generally very small (i.e. micrometer to millimeter scale). As the organic material used in fibrin scaffolds exhibits very low X-ray attenuation, low-energy X-ray radiation is desirable to achieve sufficient contrast in the projections. Moreover, a high resolution is needed to visualize the fine features in the scaffolds. Here, conventional scintillation detectors suffer two problems that make the aforementioned LAD superior for the imaging of the investigated scaffolds: a wide point-spread function and low sensitivity at low energies. Despite the high LAD sensitivity to low-energy photons, it was necessary to apply several correction procedures to achieve the highest possible resolution. Here, a computational procedure was developed to compensate for the drift of the tube’s focal spot, geometrical imperfections of the LAD detector assembly, and the effects of its border pixels with different responses and sizes. We demonstrate the results on the final reconstructed images based on uncorrected and corrected projections, where we achieved a 1 μm voxel size.
Pracoviště	Ústav teoretické a aplikované mechaniky
Kontakt	Kulawiecová Kateřina, kulawiecova@itam.cas.cz, Tel.: 225 443 285
Rok sběru	2019
Elektronická adresa	https://doi.org/10.1088/1748-0221/13/12/C12006

Počet záznamů: 1