X-ray-based microstructural analysis of low attenuaing biocompatible porous materials under simulated physiological conditions

0485997 - ÚTAM 2019 RIV DE eng C - Konferenční příspěvek (zahraniční konf.)
Kytýř, Daniel - Zlámal, Petr - Koudelka_ml., Petr - Doktor, Tomáš - Kumpová, Ivana - Vopálenský, Michal - Heimel, P. - Mühleder, S. - Senck, S.
X-ray-based microstructural analysis of low attenuaing biocompatible porous materials under simulated physiological conditions.
iCT conference 2018. 8th Conference on Industrial Computed Tomography, Wels, Austria (iCT 2018). Bad Breisig: NDT.net, 2018, č. článku 151. The Web's Largest Open Access Database of Nondestructive Testing (NDT). ISSN 1435-4934.
[Conference on Industrial Computed Tomography (ICT) 2018 /8./. Wels (AT), 06.02.2018-09.02.2018]
GRANT EU: European Commission(XE) ATCZ38 - Com3d-XCT; European Commission(XE) ATCZ133 - Kompetenzzentrum MechanoBiologie
Institucionální podpora: RVO:68378297
Klíčová slova: gellan gum hydrogel * wet condition * microtomography
Obor OECD: Materials engineering
http://www.ndt.net/article/ctc2018/papers/ICT2018_paper_id151.pdf

The presented paper is focused on the assessment of imaging procedures of the porous hydrogel-based structure reinforced by bioactive nano-particles as promising material for the tissue engineering. In this case this material is used for the scaffold and ability of reliable imaging of the complex inner structure is crucial for determination of the mechanical behaviour at microstructural level. Microtomographical data are useful for inspection and proper evaluation of the internal microstructural deformations of complex sample and also for the assessment of spatial strain field using numerical computational technique (e.q. digital volume correlation technique). In this study three types of gellan-gum bioactive-glass scaffold samples with different SiO2 content (70 wt%, 50 wt%, 0 wt%) were scanned using three different types of devices and reconstructed to obtain image data for study of morphological characterisation of the sample and further strain assessment and numerical model development. One of the scanning device is conventional commercially available μCT, second device is Talbot-Lau grating interferometer μCT and third setup is patented (EP2835631) custom build μCT setup called TORATOM. All samples are immersed into water to simulate approximate physiological conditions during the scanning. This presents a challenge with
respect to the scaffold's material with low attenuation of X-rays. Obtained image data are compared between each other and suitability of different scanning procedures is discussed.
Trvalý link: http://hdl.handle.net/11104/0281670